Pathologie: Die TMPRSS2-ERG-Genfusion im Prostatakarzinom
نویسندگان
چکیده
منابع مشابه
Die Ernahrung. Physiologie, Pathologie, Therapie
This book is divided into fourteen chapters, each written by a separate author. The titles are: Food Chemistry, Physiology of Nutrition, Food Technology, Malnutrition and Overeating, Dietetics, Physiology and Pathology of Child Nutrition, Nutrition of Population, Physiology of Vitamins, Symptoms and Therapy of A-avitaminosis, Symptoms and Therapy of E-avitaminosis, B-vitamins, Vitamin C, Ricket...
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Fusion genes play important roles in tumorigenesis. The identification of the high-frequency TMPRSS2 fusion with ERG and other ETS family genes in prostate cancer highlights the importance of fusion genes in solid tumor development and progression. However, the mechanisms leading to these fusions are unclear. We investigated whether androgen, through stimulating its receptor, could promote spat...
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Bone metastasis is the major deleterious event in prostate cancer (PCa). TMPRSS2-ERG fusion is one of the most common chromosomic rearrangements in PCa. However, its implication in bone metastasis development is still unclear. Since bone metastasis starts with the tropism of cancer cells to bone through specific migratory and invasive processes involving osteomimetic capabilities, it is crucial...
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The search for the biomarkers to precisely and non-invasively characterize the biology of prostate cancer (PCa) is the focus of many laboratories across the world. Although prostate-specific antigen (PSA) remains the standard diagnostic tool for PCa, its low specificity leads to unnecessary biopsies in a substantial number of patients. More importantly, with the current status of knowledge, it ...
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The transmembrane protease serine 2:v‑ets erythroblastosis virus E26 oncogene homolog (TMPRSS2:ERG) gene fusion is common in prostate cancer, while its functional role is not fully understood. The present study aimed to investigate the significance of the TMPRSS2:ERG gene fusion in human prostate cancers using bioinformatics tools. Comprehensive alteration analysis of TMPRSS2 and ERG in 148 dif...
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ژورنال
عنوان ژورنال: Swiss Medical Forum ‒ Schweizerisches Medizin-Forum
سال: 2011
ISSN: 1424-4020,1424-3784
DOI: 10.4414/smf.2011.07400